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      Tølbøl Sørensen, K.; Kristensen, A. Label-Free Monitoring of Diffusion in Microfluidics. Micromachines 2017, 8, 329. DOI: 10.3390/mi8110329

      Label-free, real-time detection of concentration gradients is demonstrated. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, small (glucose, 180 Da) and large (BSA, 67 kDa).

       

      Title

      Label-free monitoring of diffusion in microfluidics

      Authors

      Sørensen, K. T., & Kristensen, A. 

      Abstract

      Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa).

      Citation

      Tølbøl Sørensen, K.; Kristensen, A. Label-Free Monitoring of Diffusion in Microfluidics. Micromachines 2017, 8, 329.